Searchable abstracts of presentations at key conferences in endocrinology

ea0031p341 | Steroids | SFEBES2013

An audit of adrenal venous sampling at University College Hospital, London

Rathore Ali , Garg Anukul , Conway Gerard

Introduction: Adrenal venous sampling (AVS) is the reference standard test to differentiate between unilateral and bilateral adrenal diseases in patients with primary hyperaldosteronism. Current Endocrine society guidelines recommend AVS in all cases of primary hyperaldosteronism where surgery is desirable and practical. However, this procedure is technically challenging and failure rate is high.Aims: The aim of this audit was to evaluate success rate of...

ea0025p353 | Thyroid | SFEBES2011

Langerhans cell histiocytosis of the thyroid gland -does it needs prophylactic thyroidectomy?

Suresh Damodharan , Conway Gerard , Larosa Clementina

Langerhans cell histiocytosis (histiocytosis X) is a rare, proliferative monoclonal histiocytic disease of unknown cause that can involve many systems. Intermediate forms of the disease are characterized by a chronic course of a multi-organ involvement, including skin, bone lesions, interstitial lung disease, diabetes insipidus and rarely can involve primarily the thyroid gland.A 23-year-old gentleman presented with weight gain, lethargy and headaches. I...

ea0019p206 | Growth and development | SFEBES2009

Natural history of CHARGE syndrome in adults clinic

La Rosa Clementina , Suresh Damodharan , Conway Gerard

CHARGE syndrome describes a pattern of birth defects which occurs in about one in every 9–10 000 births worldwide. It consists of a combination of congenital malformations: coloboma, heart defect, choanal atresia, delayed development, genital hypoplasia, ear abnormalities, and/or hearing loss defect. Casual mutations involve the chromodomain helicase DNA-binding protein-7 (CHD7). Gene locus 8q12.1, 7q21.1. The phenotype can also be caused by mutation in the semapho...

ea0015p99 | Clinical practice/governance and case reports | SFEBES2008

The assessment of long-term use of testosterone replacement therapy in men with hypoganadism

Band Margaret , Llahana Sofia , Conway Gerard

Objectives: To assess the physiological benefits and side effects of testosterone replacement therapy (TRT) in routine use.Methods: A search of a historic database of 427 men using TRT identified 135 men lost to follow-up, 19 men who had insufficient data and 273 current attendees who formed the study group. A retrospective review of clinical records focused on bone mineral density (BMD) as the beneficial outcome and raised haematocrit (HCT) and prostate...

ea0051oc4.7 | Oral Communications 4 | BSPED2017

Adverse effects of delayed induction of puberty in girls Turner syndrome: Turner Syndrome Life Course Project

Cameron- Pimblett Antoinette , Talaulikar Vikram Sinai , Davi Melanie , Conway Gerard

Background: The Turner Syndrome Life Course Project, UCLH, has collected data on 810 women with TS, attending clinic for 20 years and has accumulated over 8000 clinic visits. We present an analysis of the effects of timing and type of exogenous oestrogen on health outcomes in adults.Methods: A cross-sectional analysis of 475 subjects with primary amenorrhoea with accurate age of pubertal induction data was performed using correlation coefficients control...

ea0063p951 | Diabetes, Obesity and Metabolism 3 | ECE2019

Characterisation of Turner syndrome glucose homeostasis; autoimmunity, adiposity and insulin sensitivity

Cameron-Pimblett Antoinette , Attard Carol Cardona , Conway Gerard S

Introduction: Women with Turner syndrome (TS) have an increased risk of diabetes mellitus (DM) the pathogenesis of which is not well understood. International guidelines for TS recommend oral glucose tolerance tests (OGTT) but the utility of this test has not been determined. We sought to establish the rate of IGT and DM and characterise the DM-phenotype in adult women with TS.Methods: We performed OGTTs in 37 adults with TS and obtained an additional fa...

ea0048cp3 | Poster Presentations | SFEEU2017

Vitamin B very strong – complex endocrine dysfunction

Deore Mahesh , Stokes Felicity , Srirangalingam Umasuthan , Conway Gerard

A 40 years old man with a diagnosis of Adrenoleukodystrophy (ALD) was referred for evaluation of symptoms suggestive of hypogonadism. He had a past medical history of ALD associated adrenal insufficiency and osteoporosis. He took regular hydrocortisone and a trial medication, MD1003.Following review, post clinic blood tests revealed a testosterone 24.5 nmol/l (7.6–31.4), LH 8.8 IU/l (1.7–8.6) and FSH 1.5 IU/l (1.5–12.4). Thyroid function t...

ea0044p205 | Reproduction | SFEBES2016

An audit of success rates of the induction of spermatogenesis clinic at University College London Hospitals

Dimakopoulou Anastasia , Ojewuyi Taofeek , Llahana Sofia , Baldeweg Stephanie , Conway Gerard

Introduction and aim: In the UK, 15% of couples are affected by infertility which is due to primary or secondary male factors in 30%. Induction of spermatogenesis with gonadotrophins is a long established endocrine treatment for gonadotrophin deficiency. However, there are concerns that some patient groups have very low success rates. The aim of our audit was to define success of spermatogenesis and fertility rates amongst these men.Methods: We retrospec...

ea0044p223 | Reproduction | SFEBES2016

Outcome of ovarian stimulation for oocyte cryopreservation in women with Turner Syndrome

Talaulikar Vikram , Pimblett Antoinette , Davies Melanie , Conway Gerard

Approximately 20% of women with Turner syndrome (TS) proceed normally through puberty with spontaneous menstruation. An increasing number of women with TS are taking advantage of oocyte cryopreservation which is becoming widely available. It may be expected however, that controlled ovarian stimulation would result in fewer than expected number of oocytes compared to women without TS. We report our initial results from women with TS undergoing this procedure.<p class="abste...

ea0021p89 | Clinical practice/governance and case reports | SFEBES2009

Severe primary hyperparathyroidism (PHPT) and osteomalacia in pregnancy complicated by post parathyroidectomy hypocalcaemia related transient congestive cardiac failure (CCF): a case report

Thorogood Natasha , Kurzawinski Tom , Conway Gerard , Baldeweg Stephanie

Introduction: PHPT is reported to be rare in pregnancy, with 150 cases described in the literature. Its incidence is 8/100 000 in childbearing women/year. PHPT may lead to a loss of up to 50% of pregnancies through miscarriage or stillbirth, dehydration, hyperemesis, nephrolithiasis, pre-eclampsia, fractures and pancreatitis in mothers; and death, hypocalcaemia and tetany in neonates. Intrauterine growth retardation, low birth weight and pre-term labour were described. Rate of...